Doctor’s Best Benfotiamine is a fat-soluble highly bioavailable derivative of thiamine (Vitamin B1).* Benfotiamine is activated in the bloodstream to release thiamine, and remains available in the body four times longer than water-soluble thiamin.* Benfotiamine activates transketolase, a cellular enzyme essential for glucose metabolism pathway.* It helps support the circulatory and nervous systems with radical-scavenging action against oxidative stress, providing a positive influence on Advanced Glycation End products (AGEs).*
GLUCOSE METABOLISM SUPPORT – Glucose is one of our body’s best sources of energy - and is available through bread, fruits, vegetables and more. Taking Benfotiamine daily can assist in regulating glucose levels, already within normal range, and help to counter the serious health issues related to sustained high blood sugar.*
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Listed Price$13.065,458 reviews
Product Description
Benfotiamine raises the blood level of thiamine pyrophosphate (TPP), the biologically active co-enzyme of thiamine. Thiamine and its co-enzyme, TPP thiamine (vitamin B1) plays an essential part in the metabolism of glucose, through actions of it co-enzyme TPP (thiamine pyrophosphate). TPP is formed by the enzymatically catalyzed addition of two phosphate groups donated by ATP to thiamine. TPP also goes by the name thiamine diphosphate. In the cytoplasm of the cell, glucose, a 6-carbon sugar, is metabolized to pyruvic acid, which is converted into acetyl-CoA, otherwise known as active acetate. Acetyl CoA enters the mitochondrion, where it serves as the starting substrate in the Kreb's cycle citric acid cycle. The Krebs cycle is the primary source of cellular metabolic energy. TPP, along with other co-enzymes, is essential for the removal of CO2 from pyruvic acid, which in turn is a key step in the conversion of pyruvic acid to acetyl CoA. CO2 removal from pyruvic acid is called oxidative decarboxylation and for this reason, TPP was originally referred to as cocarboxylase. TPP is thus vital to the cell's energy supply. Benfotiamine helps maintain healthy cells in the presence of blood glucose. Acting as a biochemical super-thiamin, it does this through several different cellular mechanisms, as discussed below. Benfotiamine and glucose metabolism benfotiamine normalizes cellular processes fueled by glucose metabolites. As long as glucose remains at normal levels, excess glucose metabolites do not accumulate within the cell. The bulk of the cell's glucose supply is converted to pyruvic acid, which serves as substrate for production of acetyl CoA, the primary fuel for the krebs cycle. Of the total amount of metabolic energy (in the form of ATP) released from food, the Krebs cycle generates about 90 percent.
Top Reviews from the United States
Important supplement for neuropathy
"Benfotiamine is vitamin B1 (thiamine) in the most bioavailable form possible, a fat-soluble version which can be taken orally in large, therapeutic dosages because it will not quickly flush out of the body the way ordinary vitamin B1 does.
I bought this particular brand because, frankly, it was the only brand currently offered on Amazon that came in 300 mg capsules, and I wanted to get it right away through Prime. I had suffered trauma to my mandibular nerve in a dental procedure, and research has indicated that benfotiamine is excellent for neuropathy. Yes, that research has been centered particularly on peripheral neuropathy due to the disease process of diabetes but, in my opinion, if it could work for disease-damaged nerves, it would very likely help an injured nerve as well.
The recommended dosage for neuropahy is 300 mg, two times per day. Important Note: Take this and all other B vitamins with food to avoid stomach upset.
The way that benfotiamine works to heal damaged nerves is through supporting the body's production of adenosine triphosphate. ATP is an energy-bearing molecule that is found in all living cells and is produced by the cells' mitochondria. Many different crucial, energy-consuming metabolic processes at the cellular level are made possible by ATP. In particular, ATP supports the effective transmission of the impulses of all three types of nerves in the body: (1) Sensory nerves produce the immediate sensation of touch/position or the delayed sensation of pain/temperature. (2) Motor nerves carry signals from the brain via the spinal cord to produce movement in muscles. (3) Mixed nerves can produce both sensation and movement.
Additional helpful nutraceuticals to raise ATP are:
MethylCobalamin (methyl B12): This is the most bioavailable form of B12, which can be immediately utilized by the body. When regular B12 is consumed, the body has to convert it into the methyl B12 in the gut. Ideally, it is taken sublingually, so it can go immediately into the bloodstream. The recommended dosage is 1000 mcg/day up to as much as 9000 mcg. I bought the "
Great product for nerve damage
"This supplement really stoped my carpal tunnel pain and sciatica pain along with alpha lapoic acid. Please use it"
GREAT STUFF!!
"I have suffered from diabetic neuropathy for years! Metformin attacked my nerves in the hands and feet. Switched to Ozempic and Jardience. Benfotiamine 300mg twice daily has reduced my prickly pain, swelling in my hands and feet. I have only been taking Benfotiamine with Lipoic Acid 3 days. I can play my guitar again, hold the steering wheel and use my hands again. I strongly recommend this supplement."
More About This Item
MAINTAINS NERVOUS SYSTEM HEALTH – by taking Benfotiamine the blood levels of vitamin B1 can be boosted, supporting the body’s nerves and nervous system.*
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Discount0%4.6 ratings
Our Price$1306of 5 stars
Listed Price$13.065,458 reviews
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*These statements have not been evaluated by the Food and Drug Administration. This product in not intended to diagnose, treat, cure or prevent any disease.
Benfotiamine (S-benzoylthiamine-O-monophosphate) is a derivative of thiamin, belonging to the family of compounds known as allithiamines. Benfotiamine is fat-soluble and more bioavailable and physiologically active than thiamin.*
Benfotiamine raises the blood level of thiamin pyrophosphate (TPP), the biologically active co-enzyme of thiamin, and stimulates transketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways.*
What are the benefits from Benfotiamine?
Helps maintain healthy cells in the presence of blood glucose*
Provides support against oxidative stress, and supports healthy aging.*
Why take Benfotiamine?
Benfotiamine is an ingredient derived from thiamine (a B vitamin also known as vitamin B1).*
Benfotiamine can improve levels of thiamine and, protect against health conditions related with low thiamine levels.*
How does it work?
Benfotiamine is fat-soluble and more bioavailable and physiologically active than thiamin.*
Stimulates transketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways.*
What is Doctor’s Best Benfotiamine?
Benfotiamine (S-benzoylthiamine-O-monophosphate) is a synthetic derivative of thiamin (Vitamin B1) belonging to the family of compounds known as allithiamines. Benfotiamine is fat-soluble and more bioavailable and physiologically active than thiamin.* Benfotiamine helps maintain healthy cells in the presence of blood glucose, provides support against oxidative stress, and supports healthy aging.*
How does it work?
Benfotiamine raises the blood level of thiamin pyrophosphate (TPP), the biologically active coenzyme of thiamin, and stimulates transketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways. Benfotiamine can greatly improve thiamin status, especially in comparison with regular forms of thiamin. In a randomized, double-blind crossover trial comparing bioavailability of benfotiamine to that of thiamin mononitrate (the most common supplemental form of vitamin B1) in 12 individuals, benfotiamine caused an average 5-fold greater increase in blood thiamin levels than thiamin mononitrate, with a concomitant greater thiamin concentration in red blood cells. Benfotiamine is converted to S-benzoylthiamin (through removal of the O-monophosphate by the digestive tract), which readily passes through intestinal cells and is converted into thiamin.
Why take Best Benfotiamine?
Benfotiamine is fat-soluble and more bioavailable and physiologically active than thiamin.* Benfotiamine helps maintain healthy cells in the presence of blood glucose, provides support against oxidative stress, and supports healthy aging.* Benfotiamine helps maintain healthy glucose metabolism by increasing blood and tissue levels of thiamine pyrophosphate (TPP), the biologically active co-enzyme form of thiamine.*TPP acts as a co-enzyme for three critical enzymes involved in glucose metabolism: 1) transketolase, 2) pyruvate dehydrogenase, and 3) a-ketogutarate decarboxylase. The latter two enzymes are involved in utilizing glucose for fuel. Thus, TTP is vital to the cell’s energy supply
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